Phillipp Hartmann,1 Wei-Chung Chen,2 and Bernd Schnabl1,*examine the relationship between alcohol consumption, leaky gut and SIBO. Alcoholic liver disease is one of the leading causes of death in the United States, half of which are alcohol related. Understanding, the Gut-Liver access and migration of bacteria will lead to improved treatment. Research suggests that treatment with antibiotics, probiotics, prebiotics and synbiotics may all be factors in developing treatments for dysbiosis. See the following publications, featured in “Frontiers”.